发明名称 |
Methods and compositions for inactivating glutamine synthetase gene expression |
摘要 |
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. |
申请公布号 |
AU2009311697(B2) |
申请公布日期 |
2014.12.18 |
申请号 |
AU20090311697 |
申请日期 |
2009.10.29 |
申请人 |
SANGAMO BIOSCIENCES, INC. |
发明人 |
LIU, PEI-QI;MILLER, JEFFREY C. |
分类号 |
C07K14/00;C07H21/04;C07K2/00;C12N5/00;C12N15/00;C12N15/11;C12P21/06;C12Q1/00;C12Q1/16 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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