发明名称 LONG INTERSPERSED NUCLEAR ELEMENTS (LINE-1) AND ALU HYPOMETHYLATION AS BIOMARKERS FOR COLORECTAL CANCER METASTASIS
摘要 <p>A method for determining a colorectal cancer metastasis in a human subject suffering from a primary colorectal cancer (CRC) is described herein. The method of the present invention comprises the steps of: i) identifying the human subject suffering from the primary CRC, ii) obtaining one or more biological samples from the human subject, iii) detecting a methylation level of Alu, LINE-1, or both in the one or more biological samples, and iv) increasing the level of the colorectal metastatic stage in the human subject when the methylation level of Alu, LINE-1 is lower compared to a corresponding control methylation level of Alu, LINE-1.</p>
申请公布号 EP2686452(A4) 申请公布日期 2014.12.17
申请号 EP20120761497 申请日期 2012.02.29
申请人 BAYLOR RESEARCH INSTITUTE 发明人 GOEL, AJAY;BOLAND, C., RICHARD;HUR, KEUN
分类号 C12Q1/68;G01N33/50 主分类号 C12Q1/68
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