| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new PPARγagonist. <P>SOLUTION: A 1,3,4,9-tetrahydropyrano[3,4-b]indole derivative of general formula [1] (wherein R<SP>2</SP>-A- is carboxyalkylene, and for example, B represents sulfur and X represents oxygen) and a tetrahydro-β-carboline derivative have a PPARγactivating action, and are useful as pharmaceutical agents for preventing or treating chronic diseases such as diabetes, atherosclerosis, rheumatoid arthritis, inflammatory intestinal diseases, and Alzheimer's disease. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
