发明名称 |
ADAM6 mice |
摘要 |
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided. |
申请公布号 |
EP2813573(A1) |
申请公布日期 |
2014.12.17 |
申请号 |
EP20140176593 |
申请日期 |
2012.02.24 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD, LYNN;STEVENS, SEAN;MURPHY, ANDREW J. |
分类号 |
C12N15/85;A01K67/027;C07K16/28;C07K16/40;C07K16/46;C12N9/64 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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