METHODS FOR MODULATING KALLIKREIN (KLKB1) EXPRESSION
摘要
Disclosed herein are methods for decreasing kallikrein and treating or preventing inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to kallikrein include hereditary angioedema (HAE). Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for developing an inflammatory condition, such as, hereditary angioedema.
申请公布号
EP2717923(A4)
申请公布日期
2014.12.17
申请号
EP20120796547
申请日期
2012.06.08
申请人
ISIS PHARMACEUTICALS, INC.
发明人
BHATTACHARJEE, GOURAB;REVENKO, ALEXEY;MACLEOD, ROBERT, A.