| 发明名称 | Modulation of yeast-based immunotherapy products and responses | ||
| 摘要 | Disclosed are methods to modulate yeast-based immunotherapy products and the immune responses, prophylactic responses, and/or therapeutic responses elicited by such products. Also disclosed are modified yeast-based immunotherapy products, kits and compositions. | ||
| 申请公布号 | US8911722(B2) | 申请公布日期 | 2014.12.16 |
| 申请号 | US201013395965 | 申请日期 | 2010.09.14 |
| 申请人 | The Regents of the University of Colorado, a body corporate | 发明人 | Bellgrau Donald;Tamburini Beth |
| 分类号 | A61K39/39;A61K39/395;A61K36/06;C12Q1/02;A61K39/00 | 主分类号 | A61K39/39 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. |
| 主权项 | 1. A method to inhibit the production or survival of CD4+ TH17 cells in a subject, comprising administering to a subject: a) a yeast-based immunotherapy composition comprising a whole yeast and an antigen; and b) an agent that inhibits the production or survival of CD4+ TH17 cells, wherein the agent inhibits interleukin-6 (IL 6), and wherein the agent is selected from an antibody or antigen binding portion thereof, or a soluble inactive form of IL-6 or its receptor; wherein the administration of the agent is prior to, in conjunction with, and/or following administration of the yeast-based immunotherapy composition, and wherein the production or survival of CD4+ TH17 cells is inhibited in the subject. | ||
| 地址 | Denver CO US | ||