发明名称 |
STABILIZATION OF LIQUID SOLUTIONS OF RECOMBINANT PROTEIN FOR FROZEN STORAGE |
摘要 |
The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of -56 °C or higher. |
申请公布号 |
CA2683317(C) |
申请公布日期 |
2014.12.16 |
申请号 |
CA20082683317 |
申请日期 |
2008.04.22 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
TSVETKOVA, NELLY;JOSHI, OMKAR;WU, PAUL;WANG, DEQIAN;DESPONDS, ARNAUD |
分类号 |
A61K47/26;A61K9/08;A61K38/37;A61K47/02;C07K1/02 |
主分类号 |
A61K47/26 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|