Host cell specific binding molecules capable of neutralizing viruses and uses thereof

摘要

Provided are human binding molecules that specifically bind to a host cell protein and have virus neutralizing activity, nucleic acid molecules encoding such human binding molecules, compositions comprising the human binding molecules, and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of viral infections.

主权项

1. A composition comprising a monoclonal antibody comprising a heavy and a light chain, wherein
the heavy chain comprises the CDR1 region of SEQ ID NO:12, the CDR2 region of SEQ ID NO:13, and the CDR3 region of SEQ ID NO:6; and the light chain comprises:
the CDR1 region of SEQ ID NO:14, the CDR2 region of SEQ ID NO:15, and the CDR3 region of SEQ ID NO:16,or the sequence of SEQ ID NO:74.