发明名称 | Diagnostic substance and method for the analysis of metabolism processes in the brain | ||
摘要 | The present invention relates to a diagnostic substance, containing at least one complex of lipophilic anions and metal ions, wherein the lipophilic anions are selected from the group comprising: triethylene tetramine dihydrochloride (TETA), ethyl cysteinate dimer (ECD), methoxyisobutylisonitrile (MIBI), HMPAO (d,l-hexamethylpropylene aminoxime), ethylenediamine N,N,N′,N′-tetraacetanilide (EDTAN), dimethyldithiocarbamate (DMC) and diethyldithiocarbamate (DDC) and glycine N,N′-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis [N-(carboxymethyl)-1,1′-bis[2-(octadecyloxy)ethyl]ester (DP-109), and wherein the metal ions are selected from the group comprising thallium isotopes, lead isotopes, cobalt isotopes and manganese isotopes, together with solvents, adjuvants and/or vehicles. The diagnostic substance is used for investigating metabolic processes in the brain and/or central nervous system (CNS). | ||
申请公布号 | US8911705(B2) | 申请公布日期 | 2014.12.16 |
申请号 | US200612087275 | 申请日期 | 2006.12.29 |
申请人 | Leibniz-Institut fuer Neurobiologie Stiftung des Oeffentlichen Rechts | 发明人 | Ziabreva Iryna;Henrich-Noack Petra;Goldschmidt Juergen;Baldauf Kathrin;Scheich Henning;Reymann Klaus G.;Schroeder Ulrich H.;Pforte Claudia;Riek-Burchardt Monika |
分类号 | A61K51/00;A61M36/14;A61K49/00;A61K49/10;A61K51/04 | 主分类号 | A61K51/00 |
代理机构 | Kriegsman & Kriegsman | 代理人 | Kriegsman & Kriegsman |
主权项 | 1. A method for investigating changes in cation metabolism in the brain, the method comprising the steps of: administering to a mammal a diagnostic substance containing 201Tl-DDC as well as solvents, adjuvants and/or vehicles; measuring the distribution of the 201Tl-ion contained in the diagnostic substance in brain tissue using SPET imaging; identifying changes in cation metabolism by detecting presence or absence of 201Tl-ions; wherein the method is performed in vivo. | ||
地址 | Magdeburg DE |