Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection

摘要

The methods and devices disclosed herein pertain to the percutaneous treatment of various forms of aortic dissection by at least partially filling the false lumen of the aortic dissection with a stabilization agent percutaneously and steps to decrease the size of the false lumen using the devices. Fluid maybe aspirated from the false lumen to decrease the volume of the false lumen. And the entrance opening between the true lumen and the false lumen may be sealed with a sealing agent such as a biocompatible adhesive. The medical devices disclosed herein generally comprise an extendable sealing element that is used in conjunction with a catheter to expand the true lumen while reducing the size of the false lumen. The device has the ability to aspirate and/or deliver fluid containing the stabilization agent into the false lumen.

主权项

1. A method for percutaneously treating aortic dissection in which diseased aorta comprises a true lumen, a false lumen, and an entrance opening between the true lumen and the false lumen, the method comprising,
percutaneously decreasing the volume of the false lumen by deploying an expandable device in the true lumen, with the expandable device deployed, at least partially filling the false lumen percutaneously with a stabilization agent that comprises a tissue stabilizer, a bioactive strength enhancer, a filler, an adhesive or combinations thereof, after at least partially filling the false lumen, removing completely the expandable device from the true lumen.