| 发明名称 | Purkinje cell-tropic viral vector | ||
| 摘要 | The present invention relates to a Purkinje cell-tropic viral vector in which a modified L7 promoter and a therapeutic gene are operably linked to a virus-based plasmid vector. | ||
| 申请公布号 | US8912315(B2) | 申请公布日期 | 2014.12.16 |
| 申请号 | US200712224827 | 申请日期 | 2007.03.07 |
| 申请人 | Japan Science and Technology Agency | 发明人 | Hirai Hirokazu;Torashima Takashi |
| 分类号 | C12N7/00;C12N7/02;C12N15/85;A61K48/00;C12N15/86;A61K38/17 | 主分类号 | C12N7/00 |
| 代理机构 | Wenderoth, Lind & Ponack, L.L.P. | 代理人 | Wenderoth, Lind & Ponack, L.L.P. |
| 主权项 | 1. A cerebellar Purkinje cell-tropic vector comprising a L7 promoter operably linked to a foreign gene operably linked to a virus-based plasmid vector, wherein the L7 promoter is selected from the group consisting of: a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO:3, b) a DNA consisting of the nucleotide sequence shown in SEQ ID NO:4, and c) a DNA consisting of a nucleotide sequence fragment of SEQ ID NO:3 that contains at least the nucleotide sequence of 317 to 1322 of SEQ ID NO: 1. | ||
| 地址 | Saitama JP | ||