Rock inhibitors

摘要

The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

主权项

1. A method for the treatment of an eye disease or disorder selected from the group consisting of retinopathy, optic neuropathy, glaucoma, inflammatory eye diseases and degenerative retinal diseases, comprising:
administering a compound of Formula IIaa or a stereoisomer, tautomer, racemic, salt, hydrate, or solvate thereof to a subject in need of treatment,WhereinX is hydrogen or fluoro;R1 represents hydrogen or C1-4alkyl;R21 is selected from C1-6alkyl, 3,4-dihydro-1(2H)-benzopyranyl substituted with oxo, and phenyl.