摘要 |
A new pharmaceutical formulation, especially for trans-tympanic or intra-trans~tympanic administration, containing a quinoxalin-2-one compound of the formula (I) in which R1 and R2, independently of one another, are hydrogen, methyl-, ethyl-, propyl-, butyl- or R1 and R2 together are a cyclo-alkyl compound; R3 is methoxy, ethoxy, hydroxy, hydrogen, C1-C4 alkyl or halogen, and n = 1, 2 or 3, or a pharmaceutically compatible salt of the afore-mentioned derivatives, and in addition an effective amount of a permeability accelerator of the afore-mentioned quinoxalin-2-one compound, as well as, if necessary, a pharmaceutically compatible a solvent. |