| 发明名称 | Transgenic pig model of cystic fibrosis | ||
| 摘要 | The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions. | ||
| 申请公布号 | US8912386(B2) | 申请公布日期 | 2014.12.16 |
| 申请号 | US201113288720 | 申请日期 | 2011.11.03 |
| 申请人 | University of Iowa Research Foundation;The Curators of the University of Missouri | 发明人 | Welsh Michael J.;Rogers Christopher S.;Prather Randall S.;Engelhardt John;Yan Ziying |
| 分类号 | A01K67/00;A01K67/033;A01K67/027 | 主分类号 | A01K67/00 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A transgenic pig whose genome comprises a homozygous deletion of the codon for phenylalanine at position 508 of the CFTR protein of said pig, wherein said pig has a symptom of cystic fibrosis in its pancreas, intestine, liver, or gall bladder, and does not express wild-type CFTR. | ||
| 地址 | Iowa City IA US | ||