| 发明名称 |
Methods for preparing ritodrine hydrochloride |
| 摘要 |
Methods for preparing Ritodrine hydrochloride are provided. Also provided is non-hygroscopic, crystalline, polymorphic Ritodrine hydrochloride of Form I. |
| 申请公布号 |
US8912360(B2) |
申请公布日期 |
2014.12.16 |
| 申请号 |
US201113643101 |
申请日期 |
2011.03.24 |
| 申请人 |
Lundbeck Pharmaceuticals Italy S.p.A. |
发明人 |
Zanon Jacopo;Libralon Giovanna;De Faveri Carla;Huber Florian Anton Martin |
| 分类号 |
C07C213/00;C07C209/00;C07C217/00;C07C215/60;C07C213/08;C07C213/10 |
主分类号 |
C07C213/00 |
| 代理机构 |
|
代理人 |
Alderson Jr. Robert E. |
| 主权项 |
1. A method for preparing ritodrine hydrochloride comprising:
(a) reacting of 4-(2-bromopropionyl)phenyl methanesulfonate with benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amine to obtain 4-(2{benzyl-[2-(4-benzyloxy-phenyl)-ethyl]-amino}-propionyl)-phenyl methanesulfonate; (b) hydrolyzing of 4-(2-{benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-propionyl) -phenyl methanesulfonate to obtain 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one; (c) salificating of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]amino}-1-(4-hydroxy -phenyl-propan-1-one; and (d) catalytically hydrogenating of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride to obtain Ritodrine hydrochloride as an erythro/threo mixture about of 98:2. |
| 地址 |
Padua IT |
