Markers for and methods of targeting tumor stem cells

摘要

The invention provides methods of targeting tumor stem cells that comprise inhibiting the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. The invention further provides methods for identifying tumor stem cells comprising detecting increased levels and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. Further provided are kits and articles of manufacture comprising inhibitors of the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7. Methods for screening for inhibitors of the level and/or activity of HDAC1, HDAC7 and phosphorylated HDAC7 are also provided.

主权项

1. A method for inhibiting the proliferation of or eliminating one or more epithelial carcinoma tumor stem cells that express HDAC1 and/or HDAC7 comprising contacting said one or more cells with an effective amount of at least one inhibitor of HDAC1 and/or an effective amount of at least one inhibitor of HDAC7, wherein an epithelial carcinoma tumor stem cell sample obtained from a source of said one or more cells has been determined to have an increased level or activity of HDAC1 protein and/or an increased level or activity of HDAC7 protein as compared to a standard level.