发明名称 Glycosaminoglycan mimetics
摘要 The present invention provides composition comprising one or more glycosaminoglycan mimetics and uses thereof. The subject glycosaminoglycan mimetics are particularly useful for treatment of neuronal injuries including without limitation spinal cord injuries.
申请公布号 US8912149(B1) 申请公布日期 2014.12.16
申请号 US200812315168 申请日期 2008.11.28
申请人 California Institute of Technology 发明人 Rawat Manish;Hsieh-Wilson Linda
分类号 A01N43/04;A61K31/70;C08B37/00;A61K47/48;C08G61/12 主分类号 A01N43/04
代理机构 Wilson Sonsini Goodrich & Rosati 代理人 Wilson Sonsini Goodrich & Rosati
主权项 1. A sulfated glycosaminoglycan mimetic polymer having a plurality of repeating subunits, wherein an individual repeating subunit of said repeating subunits is a saccharide covalently linked to a backbone, wherein the number of repeating subunits in said polymer is m, and wherein the sulfated glycosaminoglycan mimetic polymer is of a formula:oror a pharmaceutically acceptable salt or ester thereof; wherein R1, R2, R3, and R4 are each independently selected from the group consisting of hydroxyl, sulfate, and phosphate; one or more of R1, R2, R3, and R4 is a sulfate; R6 is selected from the group consisting of hydrogen, sulfite and acetyl; n is 1 or greater; wherein n1 is between 1 and 25, n2 is between 1 and 10, n3 is between 1 and 10; and m is 2 or greater.
地址 Pasadena CA US
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