| 发明名称 |
Anti-mesothelin antibodies and immunoconjugates |
| 摘要 |
The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same. |
| 申请公布号 |
US8911732(B2) |
申请公布日期 |
2014.12.16 |
| 申请号 |
US201113330414 |
申请日期 |
2011.12.19 |
| 申请人 |
Genentech, Inc. |
发明人 |
Dennis Mark;Scales Suzanna J.;Spencer Susan D.;Zhang Yin |
| 分类号 |
A61K39/44;A61K51/10;C07K16/30;A61K47/48;C07K16/28;A61K39/00 |
主分类号 |
A61K39/44 |
| 代理机构 |
|
代理人 |
Richardson Jessica L. |
| 主权项 |
1. An isolated antibody that binds to mesothelin, wherein the antibody comprises (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO:20, (ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO:21, (iii) HVR-H3 comprising the amino acid sequence of SEQ ID NO:22, (iv) HVR-L1 comprising the amino acid sequence of SEQ ID NO:17, (v) HVR-L2 comprising the amino acid sequence of SEQ ID NO:18, and (vi) HVR-L3 comprising the amino acid sequence of SEQ ID NO:19. |
| 地址 |
South San Francisco CA US |
