TOLL-LIKE RECEPTOR 4 (TLR4)-NEUTRALIZING HUMANIZED ANTIBODIES

摘要

This invention provides humanized, neutralizing monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, as well as TLR4 when not complexed with MD-2. These humanized, neutralizing monoclonal antibodies are referred to herein as hul5c1 antibodies. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics.