| 发明名称 |
Recombinant classical swine fever virus (CSFV) comprising a modified E2 protein and methods for generating said recombinant CSFV |
| 摘要 |
The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a “TAVSPTTLR” domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant CSFV, a method for generating a recombinant CSFV, and use of a recombinant CSFV. |
| 申请公布号 |
US8911744(B2) |
申请公布日期 |
2014.12.16 |
| 申请号 |
US200913141182 |
申请日期 |
2009.12.23 |
| 申请人 |
Intervet International B.V. |
发明人 |
Kortekaas Jeroen Alexander;Vloet Rianka Petronella Maria |
| 分类号 |
C12N7/01;A61P31/14;C12Q1/70;C07K16/08;C12N7/02;A61K39/12;C07K14/005;G01N33/569;C12N7/00 |
主分类号 |
C12N7/01 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An infectious replication competent recombinant classical swine fever virus (CSFV), comprising a deletion in a “TAVSPTTLR” (SEQ ID NO: 1) domain of the E2 protein of classical swine fever virus, corresponding to amino acid positions 829 to 837 of a parental CSFV polyprotein; wherein said deletion is selected from the group consisting of P833, T834, and P833 and T834. |
| 地址 |
Boxmeer NL |
