MICROBIOTA RESTORATION THERAPY (MRT), COMPOSITIONS AND METHODS OF MANUFACTURE

摘要

Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

主权项

1. A microbiota restoration therapy composition, comprising:
a mixture of an effective amount of fecal microbiota and an effective amount of a cryoprotectant; wherein the cryoprotectant includes dextrose, betaine, glycine, sucrose, polyvinyl alcohol, Pluronic F-127, Mannitol, tween 80, ethylene glycol, 1,3-propanediol, hydroxypropyl cellulose, a mixture of polyethylene glycol and glycerol, propylene glycol, or combinations thereof.