| 主权项 |
1. An intraocular implant comprising a cyclic lipid therapeutic agent, a polymer and a low melting cosolvent,
wherein the solubility parameters of the cyclic lipid therapeutic agent, the polymer and the low melting cosolvent are all within about 10 Mpa1/2 of each other; wherein the low melting cosolvent has a melt temperature of between about 50° C. and about 80° C.; wherein the cyclic lipid therapeutic agent is selected from the group consisting of bimatoprost, latanoprost, travoprost, unoprostone, prostaglandin E1, prostaglandin E2, and mixtures thereof; wherein the polymer is a biodegradable polymer selected from the group consisting of polylactic acid, polyglycolic acid, and polylactide-co-glycolide; and wherein the low melting cosolvent is selected from the group consisting of decafluorobutant, poly(hexamethylene adipamide), and polyethylene glycol 3350; wherein the cyclic lipid agent comprises 20% by weight of the intraocular implant, and wherein the potency of the cyclic lipid therapeutic agent released from the implant is at least about 50% of its maximum potency. |
