METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS

摘要

The present disclosure provides methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, including rheumatoid arthritis, having the structure of Formula (I):;;wherein R1, R2, R3, R4, R5 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.

主权项

1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:
X is CH or N;R1 is selected from the group consisting of H, C1-C6 alkyl, fluoro, chloro, bromo, cyano, or —CF3;R2 is selected from the group consisting of H, methyl, cyano, or fluoro;R3 is selected from the group consisting of: R4 is selected from the group consisting of H, methyl, OH, and O—CH3;R5 is H or C1-C3 alkyl;m is 1 or 2;n is 0 or 1;p is 1; andq is 0 or 1.