| 发明名称 |
ASSAY FOR SCREENING COMPOUNDS THAT SELECTIVELY DECREASE THE NUMBER OF CANCER STEM CELLS |
| 摘要 |
The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs). This method includes (a) contacting a CSC from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. The method may be used as a high throughput screen. |
| 申请公布号 |
US2014364402(A1) |
申请公布日期 |
2014.12.11 |
| 申请号 |
US201214005058 |
申请日期 |
2012.03.22 |
| 申请人 |
Smith Barry;Cordon-Cardo Carlos;Petrylak Daniel;Domenech Josep;Martin Mireia Castilla |
发明人 |
Smith Barry;Cordon-Cardo Carlos;Petrylak Daniel;Domenech Josep;Martin Mireia Castilla |
| 分类号 |
G01N33/50;A61K31/573;A61K31/4355;A61K31/55;C12Q1/68;G01N33/574 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs) comprising:
a. contacting a CSC from a population of cells with a candidate agent; and b. determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. |
| 地址 |
New York NY US |
