A liposome composition that is useful for treating a subject in need of cancer treatment includes a cross-linked multilamellar liposome having an exterior surface and an interior surface. The interior surface defines a central liposomal cavity. The multilamellar liposome includes at least a first lipid bilayer and a second lipid bilayer. The first lipid bilayer is covalently bonded to the second lipid bilayer. At least one anticancer compound is disposed within the multilamellar liposome. Methods for treating subjects are also provided.
申请公布号
WO2014197500(A1)
申请公布日期
2014.12.11
申请号
WO2014US40741
申请日期
2014.06.03
申请人
UNIVERSITY OF SOUTHERN CALIFORNIA
发明人
WANG, PIN;WONG, MICHAEL KK;GRAY, ANDREW;JOO, KYE-II;LIU, YARONG