| 摘要 |
The present invention relates to the field of drug delivery. More specifically, the present invention provides methods and compositions useful for transepithelial delivery of therapeutics, vaccines and diagnostics. In certain embodiments, a composition comprises a transcytosis enhancer, a cargo agent, and a pharmaceutically acceptable carrier. In a specific embodiment, the transcytosis enhancer comprises N-ethylmaleimide or derivative thereof. In a specific embodiment, the transcytosis enhancer is a Serine Protease Autotransporters of Enterobactericeae (SPATE) protease. In a more specific embodiment, the SPATE protease is Extracellular Serine Protease Plasmid (O157)-encoded) (EspP). |
