| 摘要 |
The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, represented by the following general Formula V,;;With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl. |
| 主权项 |
1. A method of making an indeno-fused naphthol represented by Formula I, wherein, m and n are each independently selected from 0 to 4, R1 for each m, and R2 for each n, are in each case independently selected from hydrocarbyl optionally interrupted with at least one of —O—, —S—, —C(O)—, —C(O)O—, —S(O)—, —SO2—, —N(R11′)— where R11′ is selected from hydrogen, hydrocarbyl or substituted hydrocarbyl, and combinations of two or more thereof; substituted hydrocarbyl optionally interrupted with at least one of —O—, —S—, —C(O)—, —C(O)O—, —S(O)—, —SO2—, —N(R11′)— where R11′ is selected from hydrogen, hydrocarbyl or substituted hydrocarbyl, and combinations of two or more thereof; halogen; cyano; and —N(R11′)R12′, wherein R11′ and R12′ are each independently selected from hydrogen, hydrocarbyl or substituted hydrocarbyl, or R11′ and R12′ together form a ring structure optionally including at least one heteroatom, and Rg and Rh are each independently selected from, hydrogen; hydrocarbyl optionally interrupted with at least one of —O—, —S—, —C(O)—, —C(O)O—, —S(O)—, —SO2—, and —N(R11′)— where R11′ is selected from hydrogen, hydrocarbyl or substituted hydrocarbyl; and substituted hydrocarbyl optionally interrupted with at least one of —O—, —S—, —C(O)—, —C(O)O—, —S(O)—, —SO2—, and —N(R11′)— where R11′ is selected from hydrogen, hydrocarbyl or substituted hydrocarbyl, or Rg and Rh together form a ring structure optionally including at least one heteroatom, said method comprising, (a) reacting an alkyl benzene represented by Formula II with maleic anhydride, thereby forming a succinic acid substituted intermediate represented by Formula III, (b) converting the succinic acid substituted intermediate represented by Formula III to a succinic anhydride substituted intermediate represented by Formula IV, (c) converting the succinic anhydride substituted intermediate represented by Formula IV to an indanone acid intermediate represented by Formula V, (d) reacting the indanone acid intermediate represented by Formula V with a nucleophile represented by Formula VI to form a substituted indanone intermediate represented by at least one of Formula VIIa, Formula VIIb and Formula VIIc, wherein M represents a counterion comprising a metal selected from Mg, Li, Cu and combinations thereof,and
(e) converting said substituted indanone intermediate represented by at least one of Formula VIIa, Formula VIIb and Formula VIIc to said indeno-fused naphthol represented by Formula I. |
