发明名称 |
AGOMELATINE FORMULATIONS COMPRISING AGOMELATINE IN THE FORM OF CO-CRYSTALS |
摘要 |
<p>A pharmaceutical formulation of agomelatine for oral use, comprising - agomelatine in the form of agomelatine co-crystals with organic acids and - pharmaceutically acceptable excipients, in which - the agomelatine co-crystals are used in the form of pre-blend of the agomelatine co- crystals with a glidant, - the ratio of the agomelatine co-crystals to the glidant in the pre-blend is lower than or equal to 30 : 1, and - the free-water content in the used pharmaceutically acceptable excipients is lower than or equal to 7% w/w.</p> |
申请公布号 |
WO2014194992(A1) |
申请公布日期 |
2014.12.11 |
申请号 |
WO2014EP01410 |
申请日期 |
2014.05.24 |
申请人 |
ZENTIVA, K.S. |
发明人 |
REZAC, JAROSLAV;PRIBYL, DANIEL;HANOVSKA, ANNA;DAMMER, ONDREJ |
分类号 |
A61K47/02;A61K31/165;A61K47/12 |
主分类号 |
A61K47/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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