发明名称 IMIDAZOLYL PROGESTERONE ANTAGONISTS
摘要 Described herein are imidazolyl compounds which either act as pure antiprogestins and methods of using such pure antagonists for gynecological indications and breast cancer.
申请公布号 US2014364600(A1) 申请公布日期 2014.12.11
申请号 US201313910273 申请日期 2013.06.05
申请人 Nickisch Klaus;Elger Walter;Santhamma Bindu 发明人 Nickisch Klaus;Elger Walter;Santhamma Bindu
分类号 C07J43/00;C07J21/00 主分类号 C07J43/00
代理机构 代理人
主权项 1. A compound having the structure of formula (I): In which: X is O or H2 R1 is a hydrogen atom, a straight-chain C1-C5 alkyl group, a branched C1-C5 alkyl group, a C3-C5 cycloalkyl group or a halogen atom; R2 is a hydrogen atom, a straight-chain C1-C5 alkyl group, a branched C1-C5 alkyl group, a C3-C5 cycloalkyl group or a halogen atom; or R1 and R2 together are a methylene group, R3 is a hydrogen atom, a straight-chain C1-C5 alkyl group, a branched C1-C5 alkyl group, a C3-C5 cycloalkyl group or a halogen atom; R4 is a hydrogen atom, a straight-chain C1-C5 alkyl group, a branched C1-C5 alkyl group, a C3-C5 cycloalkyl group or a halogen atom; or R3 and R4 together are an additional bond or a methylene group, R5 an N imidazolyl group that is optionally substituted by one or more alkyl groups R6 stands for a free, etherified or esterified hydroxyl group, R7 stands for a radical of formula CnFmHo whereby n is 2, 3, 4, 5 or 6 with m≧1 and m+o=2n+1 or 2n−1 or 2n−3
地址 Berlin DE