| 发明名称 |
METHOD AND SYSTEM FOR IDENTIFYING COMPOUNDS THAT BIND AND/OR ACTIVATE A TARGET OPIOID RECEPTOR IN A PH-DEPENDENT MANNER |
| 摘要 |
The invention relates to a method for identifying compounds that bind and preferably activate a target opioid receptor in a pH-dependent manner. |
| 申请公布号 |
US2014364449(A1) |
申请公布日期 |
2014.12.11 |
| 申请号 |
US201314370691 |
申请日期 |
2013.01.07 |
| 申请人 |
MATHPHARM GMBH |
发明人 |
Stein Christoph;Weber Marcus;Scharkol Olga;Deuflhard Peter |
| 分类号 |
G06F19/16;G06F17/50;C07D211/58;A61K49/00;G01N33/94;C07D491/08 |
主分类号 |
G06F19/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying compounds that bind and/or activate a target opioid receptor in a pH-dependent manner, comprising
a) modifying a base compound to produce a modified compound, b) determining the acid dissociation constant (pKa) of said modified compound, c) selecting said modified compound for further processing when the pKa of said modified compound is less than 7, and d) testing for binding of the modified compound to said target opioid receptor and/or activation of said target opioid receptor by the modified compound. |
| 地址 |
Berlin DE |
