| 主权项 |
1. A compound of the formula:or a pharmaceutically acceptable salt thereof,in which:
R1 is represented by C1-C3 alkyl; R2 is represented by hydrogen or C1-C3 alkyl; X is represented CH2, 0, NH, S or SO2, A is represented by phenyl or a 6-membered heteroaryl as depicted below: R3 is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxy, amino, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl, and trifluoromethoxy; L is absent, or is represented by S, SH, OH, —(CH2)p—O—(CH2)n, —(CH2)p—O—(CH2)z—O—(CH2)n—, S—(CH2)z, or (CH2)z—S; n is represented by an integer ranging from 0 to 3; p is represented by an integer ranging from 0 to 3; z is represented by an integer ranging from 1 to 3; D is absent, or is represented by a substituent selected from the group consisting of:
i) (C3-C10)cycloalkyl, optionally substituted,ii) (C3—O10)cycloalkyl(C1-C6)alkyl, in which the alkyl and cycloalkyl moieties may each be optionally substituted,iii) (C6-C10)aryl optionally substituted,iv) (C6-C10)aryl(C1-C6)alkyl, in which the alkyl and aryl moieties may each be optionally substituted,v) heteroaryl, optionally substituted,vi) heteroaryl(C1-C6)alkyl, in which the heteroaryl and alkyl moieties may each be optionally substituted,vii) heterocyclic, optionally substituted,viii) heterocyclic(C1-C6)alkyl, in which the alkyl and heterocyclic moieties may each be substituted; T is absent, or is represented by —(CH2)z—, —(CH2)n—C(O)—(CH2)p—, O—(CH2)z—, —(CH2), —O—, or —O—(CH2)p—C(O)—(CH2)n— and; G is absent, or is represented by a substituent selected from the group consisting of: i) (C3-C10)cycloalkyl, optionally substituted; ii) (C6-C10)aryl optionally substituted; iii) heteroaryl, optionally substituted, or; iv) heterocyclic, optionally substituted; with the proviso that:
a) at least one of D or L must be presentb) if D is absent, then T and G are also absent. |
