发明名称 |
REAGENTS, METHODS AND DEVICES TO PREVENT AGGREGATION IN PARTICLE BASED TESTS FOR THE DETECTION OF MULTIMERIC TARGET MOLECULES |
摘要 |
The present invention relates to a method for preventing aggregation of detection particles in a test for detecting a multi-epitope target analyte comprising two or more similar or identical epitopes in a sample and/or for determining the concentration of the multi-epitope target analyte in a sample wherein the method comprises the step of applying a first capture entity which can specifically bind to at least one epitope on the multi-epitope analyte, characterized in that the first capture entity blocks the at least one epitope from binding to a detection particle. The invention further relates to a method wherein the detection of the multi-epitope target analyte comprises the use of a second capture entity, which can specifically bind to the same or similar epitope of the multi-epitope target analyte as the first capture entity. Also envisaged is a method for the detection of said multi-epitope target analyte, the performance of the method in a system comprising a sensor surface and the use of a first capture entity to block the at least one epitope from binding to a detection particle such as a magnetic detection particle. |
申请公布号 |
WO2014195899(A1) |
申请公布日期 |
2014.12.11 |
申请号 |
WO2014IB61986 |
申请日期 |
2014.06.05 |
申请人 |
KONINKLIJKE PHILIPS N.V. |
发明人 |
EVERS, TOON HENDRIK;PRINS, MENNO WILLEM JOSE;NIEUWENHUIS, JEROEN HANS |
分类号 |
G01N33/543 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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