METHOD FOR PRODUCING BETA-HEMATIN CRYSTALS INCLUDING A HEATING STEP

摘要

The purpose of the present invention is to provide a preparation method for preparing beta-hematin crystals via a heating step, beta-hematin crystals obtained by this preparation method, and a vaccine adjuvant composition containing the beta-hematin crystals. Beta-hematin crystals having an acicular shape, an average particle size of 0.6-1.2 μm, and characteristic main peaks (including any peak having a diffraction angle within ±0.2° of the main peaks) of the diffraction angle 2&thetas; at 7.4°, 12.2°, 21.6°, and 24.1°in x-ray diffraction obtained by powder x-ray diffraction using Cu-Kα radiation.