The present invention relates to modification of RNA with 5 '-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.
申请公布号
AU2010281042(B2)
申请公布日期
2014.12.11
申请号
AU20100281042
申请日期
2010.08.03
申请人
JOHANNES GUTENBERG-UNIVERSITAT MAINZ;UNIWERSYTET WARSZAWSKI;BIONTECH AG