Aqueous Pharmaceutical Composition With Enhanced Stability

摘要

The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.

主权项

1. An aqueous pharmaceutical composition, comprising:
an ionized therapeutic agent; an ionic component; guar gum at a concentrations sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition; and water; wherein the composition has a pH that is at least 6.0, but is no greater than 8.3.