Method and Composition for In Situ Formation and/or Expansion of a Polymer-Based Hemostatic Agent to Control Bleeding

摘要

A composition for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide or chemical(s) capable of forming hydrogen peroxide, or a combination of both, and a decomposing agent for hydrogen peroxide. The decomposing agent includes an endogenously or exogenously supplied catalyst (other than catalase), or both, and/or the polymer or polymer-forming component.

主权项

1. An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:
a) providing a polymer-forming component comprising polyvinylsiloxane; b) providing hydrogen peroxide having a concentration of about 10% to 20% by volume or weight; c) delivering the polymer-forming component and hydrogen peroxide by injection into the wound or body cavity; and d) allowing the hydrogen peroxide to come in contact an endogenous or exogenous catalyst comprising platinum, thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.