发明名称 |
Methods for Predictive Automatic Gain Control for Hybrid Mass Spectrometers |
摘要 |
A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer. |
申请公布号 |
US2014361158(A1) |
申请公布日期 |
2014.12.11 |
申请号 |
US201414297092 |
申请日期 |
2014.06.05 |
申请人 |
Thermo Finnigan LLC |
发明人 |
REMES Philip M.;SENKO Michael W.;BLETHROW Justin |
分类号 |
H01J49/00;H01J49/26 |
主分类号 |
H01J49/00 |
代理机构 |
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代理人 |
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主权项 |
1. A method for performing a mass analysis of a subset of ions generated from a sample, the subset of ions comprising a restricted range mass-to-charge (m/z) ratios of the generated ions, the method comprising the steps of (i) performing a survey mass analysis using a mass analyzer of a mass spectrometer so as to identify the restricted range of m/z ratios and to measure a flux of ions having m/z ratios within said restricted range and (ii) performing a dependent mass analysis of an optimal quantity of ions having m/z ratios within said restricted range, said optimal quantity of ions collected for a time period determined by the measured ion flux, the method CHARACTERIZED IN THAT:
the time period is determined using a corrected ion flux that is calculated from the measured flux of ions, wherein the correction accounts for, during the dependent mass analysis, one or more of: (a) imperfect restriction of collected ions to the range of m/z ratios, (b) the use of different mass analyzers for the survey and dependent mass analyses, and (c) one or more ion pathways that differ from those used during the survey mass analysis; and wherein the correction accounts for ion collection that includes ions within the range of m/z ratios that are undetected by the survey mass analysis, wherein the survey mass analysis is performed by an electrostatic trap mass analyzer. |
地址 |
San Jose CA US |