| 摘要 |
PROBLEM TO BE SOLVED: To provide an antigen derived from Streptococcus pyogenes and use thereof for immunological treatment.SOLUTION: The invention provides mutants of GAS57, which cannot cleave IL-8 and similar substrates but still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies that specifically bind to GAS57 to block its ability to cleave IL-8 and other similar substrates. The mutants are useful, in particular, for vaccine compositions that induce protection against S. pyogenes. The antibodies are useful, for example, as therapeutics for treating S. pyogenes infections. |
