A MULTI-ECHO LENGTH AND OFFSET VARIED SATURATION (Me-LOVARS) METHOD FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MR IMAGING

摘要

The present invention provides a novel approach for CEST MR imaging, called Multi-echo Length and Offset VARied Saturation (Me-LOVARS) CEST. This method allows efficient collection of additional CEST data without penalty in scan time, which could be useful for enhancing the contrast, increasing the specificity or improving quantification of exchange. As CEST-MRI has shown promise at both the pre-clinical and clinical levels, including for detecting and grading brain tumors and evaluating ischemia, using either endogenous CEST contrast or through administration of CEST contrast agents. This fast and robust imaging method is suitable for accelerating image collection and widening the scope of applications for CEST-MRI.