发明名称 |
USE OF SLC39A12 PROTEINS AS TARGET IN DIAGNOSIS AND DRUG SCREENING IN ALZHEIMER'S DISEASE |
摘要 |
The present invention discloses a dysregulation of the SLC39A12 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating and preventing Alzheimer's disease and related neurodegenerative disorders using the SLC39A12 gene and its corresponding gene products. Screening methods for modulating agents of neurodegenerative diseases are also disclosed. |
申请公布号 |
EP1891234(B1) |
申请公布日期 |
2014.12.10 |
申请号 |
EP20060763457 |
申请日期 |
2006.06.01 |
申请人 |
EVOTEC INTERNATIONAL GMBH |
发明人 |
POHLNER, JOHANNES;VON DER KAMMER, HEINZ |
分类号 |
C12Q1/68;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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