Nitrocatechol derivatives as COMT inhibitors

摘要

New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.

主权项

1. A compound according to formula IVA, IVB or IVC wherein R4, R5, R6 and R7 independently from each other represent hydrogen, C1-C6-alkyl, C1-C6-thioalkyl, C1-C6-alkoxy, C6-C12-aryloxy or a C6-C12-thioaryl group, C1-C6-alkanoyl or C7-C13-aroyl group, amino, C1-C6-alkylamino, C1-C6-dialkylamino, C3-C12-cycloalkylamino or C3-C12-heterocycloalkylamino, C1-C6-alkylsulphonyl or C6-C12-arylsulphonyl, halogen, C1-C6-haloalkyl, trifluoromethyl, cyano, nitro or a heteroaryl group; and R8 and R9 independently from each other represent hydrogen or suitable protective groups for aromatic hydroxyl groups.