| 主权项 |
1. A compound represented by formula (I): wherein; W is N, wherein N is substituted with hydrogen or C1-C6 alkyl; Y is —O(CR3R4)n—; R3 and R4 are each independently hydrogen, fluorine, or C1-C6 alkyl; n is 0 or 1; R1 is a group represented by formula (IIc): X2 is a group —(CH)—, X4 is a carbon atom, and X3 and X5 are each a nitrogen atom; such that each combination thereof forms an aromatic ring system; R11 is linked to X4 and is —NRARB; RA and RB are at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl, such C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORD, —CN or halo; alternatively, RA and RB, form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated heterocyclic monocyclic or bicyclic ring system which is optionally substituted by one or more of —ORD, —CN, halo, C1-C6 alkyl or C3-C7 cycloalkyl, such C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORD, —CN or halo; and which 5-11-membered saturated heterocyclic monocyclic or bicyclic ring optionally contains a further heteroatom which is oxygen or nitrogen, said nitrogen atom optionally substituted by C1-C6 alkyl or C3-C6 cycloalkyl, wherein any of said C1-C6 alkyl or C3-C6 cycloalkyl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORD, —CN, or halo; or RA and RB may be linked to one carbon atom of the —(C1-C6alkylene)-, —(C2-C6alkylene)- or —(C3-C7cycloalkylene)- portion of the group linked to the nitrogen to which they are connected to form a saturated cycle of up to 6 ring atoms; RD is at each occurrence independently hydrogen, —CH3, or —C2H5; R13 is hydrogen, C1-C6 alkyl, or halogen; A is a divalent cycloalkylene radical having 5, 6, or 7 ring atoms; said cycloalkylene ring being attached to W and Y, and fused to a phenyl ring or to a monocyclic heteroaryl ring having 5 or 6 ring atoms, said phenyl or heteroaryl ring being optionally substituted by one or two groups R24; R24 is at each occurrence independently C1-C6 alkyl, halogen, or cyano; R2 is a group of formula (IIIb): wherein R17 is a group of formula (IV) wherein R20 is —CH3 or CH2OMe; R21 is —CH3; R18 is a lone electron pair, hydrogen, aryl, heteroaryl, —(C1-C6alkyl), —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) or (C5-C7heterocycloalkyl)-(C3-C6 cycloalkyl), wherein any of such aryl, heteroaryl, —(C1-C6alkyl), —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) and (C5-C7heterocycloalkyl)-(C3-C6 cycloalkyl) may be optionally substituted by one moiety selected from the group consisting of —CN, —OH, halo, —COORM, C1-C6alkyl, C3-C6cycloalkyl, —O—(C1-C6alkyl), —O—(C3-C6cycloalkyl), —NRHRJ, —N(RL)(C2-C6alkylene)-NRHRJ, —N(RL)(C3-C7cycloalkylene)-NRHRJ, —(C1-C6alkylene)-NRHRJ, —(C3-C7cycloalkylene)-NRHRJ, —O—(C2-C6alkylene)-NRHRJ, —O—(C3-C7cycloalkylene)-NRHRJ, —O—(C2-C6alkylene)-ORM, —O—(C3-C7cycloalkylene)-ORM, ORL, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl) and (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl), wherein any of such C1-C6alkyl, C3-C6cycloalkyl, —(C2-C6alkylene)-, —(C3-C7cycloalkylene)-, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl) and (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl) portion in the above listed groups may be optionally substituted by one moiety selected from the group consisting of C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORL or halo; RH and RJ, are at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl or C3-C6 cycloalkyl being optionally substituted by a C1-C3 alkyl group, —ORM, CN, or halo; alternatively, RH and RJ form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated monocyclic or bicyclic heterocyclic ring system which is optionally substituted by one or more of —ORM, —CN, halo, C1-C6 alkyl, or C3-C7 cycloalkyl, said C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORM, CN or halo; and which 5-11-membered saturated monocyclic or bicyclic heterocyclic ring optionally contains a further heteroatom which is oxygen or nitrogen, said nitrogen atom optionally substituted by C1-C6 alkyl or C3-C6 cycloalkyl, wherein any of said C1-C6 alkyl or C3-C6 cycloalkyl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORM, CN, or halo; and/or RH and RJ may be linked to one carbon atom of the —(C1-C6alkylene)-, —(C2-C6alkylene)- or —(C3-C7cycloalkylene)- portion of the group linked to the nitrogen to which they are connected to form a saturated cycle of up to 6 ring atoms; RL is at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl or C3-C6 cycloalkyl being optionally substituted by a C1-C3 alkyl group, —ORM, —CN, or halo; RM is at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl or C3-C6 cycloalkyl being optionally substituted by hydroxyl, —CN, or halo; z1, z2, z3, and z4 are independently C, N, O, a group —CH—, or a group —NH—, in such a combination that the resulting ring formed is a pyrazolyl ring, an imidazolyl ring, or an isoxazolyl ring, or a pharmaceutically acceptable salt thereof. |
