Single component fibrin hemostat

摘要

ClotGel is a single-component hemostatic agent designed for use as an adjunct or primary treatment in moderate intraoperative hemorrhage and in trauma. It can be applied topically to the wound either on the skin in a laparatomy or as non-invasive manner in surgical procedures. Its crosslinking technology generates an adhesive stable fibrin clot using a single component (fibrin II) required for hemostasis. The agent is a mixture of lyophilized polymerized fibrin II and fibrin II monomer which is polymerized and stabilized when in contact with the blood. The attachment properties of the gel, as well as the rapid formation of a fibrin clot, ensures that a strong stable fibrin clot is formed within 1 minute of application.

主权项

1. A composition for the control of bleeding with or without compression comprising the following two components homogenized into a single colloidal solution at the time of use:
a) a crosslinked lyophilized/homogenized desAB fibrin (fibrin II) polymer suspended in acetic acid solution at a concentration ranging from 6 mg/mL to 24 mg/mL, b) a des AB fibrin (fibrin II) monomer in acetic acid solution or sodium acetate at a concentration ranging from 6 mg/mL to 24 mg/mL, wherein the acetic acid solution or sodium acetate buffer has a pH of 3.4-4.0.