| 发明名称 |
METHOD FOR DIAGNOSING CANCERS EXPRESSING A TRUNCATED HER2 RECEPTOR VARIANT |
| 摘要 |
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognizes an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2. The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample. |
| 申请公布号 |
PT2293819(E) |
申请公布日期 |
2014.12.09 |
| 申请号 |
PT20090772265T |
申请日期 |
2009.06.05 |
| 申请人 |
FUNDACIÓ PRIVADA INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL HEBRON;FUNDACIÓ PRIVADA INSTITUCIÓ CATALANA DE RECERCA IESTUDIS AVANCATS;FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLOGICA DE VALL-HEBRON |
发明人 |
JOAQUÍN ARRIBAS LÓPEZ;KIM PEDERSEN;PIER-DAVIDE ANGELLINI;JOSEP LLUIS PARRA PALAU;SIRLE LAOS;JOSÉ BASELGA TORRES |
| 分类号 |
A61K47/48;C07K16/32;G01N33/574 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
