摘要 |
A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modified so that a system for uptake of a byproduct of the target substance or a substrate for a biosynthesis system of the target substance into the bacterial cell. <??>In preferred embodiments, the cell uptake system is Mtr or TnaB, where activity is increased by means of genetic engineering in order to produce L-Phe and smaller amounts of L-Trp. |