Nanostructures for drug delivery

摘要

The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.

主权项

1. A method of making a composition for the delivery of a hydrophilic drug comprising:
providing a hydrophobic drug precursor comprising a substantially hydrophilic small molecule drug bound to a compatibilizing moiety, and forming a particle comprising a hydrophobic interior, wherein the hydrophobic drug precursor is encapsulated in the particle in an amount of at least 0.1% by weight based on the weight of the particle.