发明名称 |
Zero-mode waveguides with non-reflecting walls |
摘要 |
The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures. |
申请公布号 |
US8906670(B2) |
申请公布日期 |
2014.12.09 |
申请号 |
US201012877764 |
申请日期 |
2010.09.08 |
申请人 |
Pacific Bioscience of California, Inc. |
发明人 |
Gray Jeremy;Cicero Ronald L.;Grot Annette;Popovich Natasha;Dudek Stephen |
分类号 |
C12M1/34;G01N21/64;G02B6/10;G01N21/77 |
主分类号 |
C12M1/34 |
代理机构 |
|
代理人 |
Reamey Robert H. |
主权项 |
1. A zero-mode waveguide structure comprising:
a) a transparent substrate having a top surface; b) an opaque layer comprising a metal disposed upon the top surface of the transparent substrate; c) an array of apertures extending through the opaque layer to the transparent substrate whereby the apertures comprise wells having walls and bases, the bases of the wells comprising portions of the top surface of the transparent substrate; and d) a non-reflective layer comprising an oxide formed by oxidation of the metal disposed on the walls of the wells wherein the thickness of the non-reflective layer is greater than about 10 nm. |
地址 |
Menlo Park CA US |