Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate

摘要

The invention provides improved processes for the preparation of hydrated form of (S)-(+)-Clopidogrel bisulfate as well as improved processes for the preparation of form-I and form-II of (S)-(+)-Clopidogrel bisulfate.

主权项

1. A process for preparing (S)-(+)-Clopidogrel bisulfate comprising:
treating (S)-(+)-Clopidogrel base with dilute H2SO4 in a solvent selected from a member of the group consisting of hexanol, 2-hexanol, 3-hexanol, isohexanol, heptanol, 2-heptanol, 3-heptanol, 4-heptanol, octanol, iso-octanol, and decanol; and isolating (S)-(+)-Clopidogrel bisulfate from the solvent.