Flavivirus inhibitors and methods of their use

摘要

Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.

主权项

1. A method of treating a Flavivirus infection in a subject, comprising administering to the subject a therapeutically effective amount of the compound of the following formula: or a pharmaceutically acceptable salt or prodrug thereof, wherein:
R1 is hydroxyl;R2, R3, R4, R5, and R6 are each independently selected from hydrogen, hydroxyl, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 heteroalkyl, substituted or unsubstituted C2-4 alkenyl, substituted or unsubstituted C2-4 heteroalkenyl, substituted or unsubstituted C2-4 alkenyl, substituted or unsubstituted C2-4 heteroalkynyl, or halogen;A is B isand
R7 is hydrogen.