| 发明名称 | Multiple antigen delivery system using hepatitis E virus-like particle | ||
| 摘要 | This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems. | ||
| 申请公布号 | US8906862(B2) | 申请公布日期 | 2014.12.09 |
| 申请号 | US201113220356 | 申请日期 | 2011.08.29 |
| 申请人 | The Regents of the University of California;National Institute of Infectious Disease;Tsukuba Primate Research Center, National Institue of Biomedical Innovation | 发明人 | Cheng R. Holland;Xing Li;Miyamura Tatsuo;Yasutomi Yasuhiro;Li Tian-Cheng;Takeda Naokazu |
| 分类号 | A61K38/16;C07K14/005;A61K39/29;A61K39/21;A61K39/00 | 主分类号 | A61K38/16 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A composition comprising: an HEV capsid protein comprising a portion of an HEV ORF 2 protein and a heterologous peptide, wherein the heterologous peptide is inserted into the portion of HEV ORF 2 within a pre-selected region corresponding to residues 483-490, residues 530-535, residues 554-561, residues 573-577, or residues 582-593, or residues 601-613 of SEQ ID NO:1; and a heterologous nucleic acid encapsulated in a chimeric HEV virus-like particle (VLP) formed by the HEV capsid protein. | ||
| 地址 | Oakland CA US | ||